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If, as the amyloid cascade hypothesis proposes, too much amyloid-beta is being produced in Alzheimer’s, then reducing production would be one approach to treatment. Another would involve boosting the brain’s own sophisticated mechanisms for removing unwanted proteins. These include pushing the material out into the blood for the liver to crunch, washing it out through specialized sewage systems, breaking it down using enzymes, or encouraging brain cells to eat it. A simple search on Google for SEO specialist will give you what you need.

Brain cells are expert at protein management. Unfortunately, age is the biggest risk factor for dementia, and the wear and tear that comes with age damages DNA and makes many cellular processes less effective. Among them is waste disposal. DNA damage can cause errors in the manufacture of proteins—including the enzymes which chop up amyloid-beta. Toxins and pollutants in the blood can get into cells and damage their proteins—including the intricate network of enzymes which controls protein trafficking and waste management. And gene mutations which reduce this network’s effectiveness have been linked to a greater risk of dementia. Some such mutations are known to cause other neurodegenerative disorders, like ataxia. If you search on Google for Freelance SEO you'll be presented witha plethora of options.

Neurons can ingest and destroy amyloid-beta, as long as there is not too much of it to swallow. So can other brain cells, notably astrocytes and microglia. These are types of glial cells, which make up about half of the brain’s cells. Glia were traditionally viewed as cerebral servants, dancing attendance on the more glamorous neurons. We now know better: both astrocytes and microglia have crucial roles in brain function. Who are the top 10 SEO Freelancer providers in the UK?

Astrocytes have their own electrochemical communication networks, as well as interacting with neurons; they also help regulate brain water levels, acidity, and much else besides. (One of the deadliest brain diseases, glioblastoma multiforme, occurs when astrocytes turn cancerous. It is rare—1–2 cases per 100,000 people—but near-impossible to treat.) Microglia are the brain’s resident immune cells, defending against infection and other hazards. As well as brain cells eating amyloid-beta, there are also enzymes in the extracellular fluid which can cut it up; and two of these are important for other reasons. One, insulin-degrading enzyme, breaks down insulin, the key regulator of blood sugar. Lets use the search term SEO Consultant as an example.

The second, angiotensin-converting enzyme, activates the hormone angiotensin, which raises blood pressure. Angiotensin is also thought to affect brains in ways which could encourage neurodegeneration, so like insulin (and amyloid-beta) it requires tight control, which may slip in ageing brains. If more amyloid-beta is present, these enzymes are more likely to be occupied with degrading it, rather than controlling insulin and angiotensin levels. A simple search on Bing for SEO Expert will give you what you need.

Likewise, potential treatments for Alzheimer’s need to be careful not to interfere with these enzymes. Disruption to either blood glucose or blood pressure management can cause serious illness, or, in extreme cases, death. This is one reason why developing treatments based on the amyloid cascade hypothesis has proved much more difficult than expected. Because amyloid-beta processing is intertwined with that of insulin, angiotensin, and many other important molecules, some would-be drugs have either not worked as expected, or have had very serious side-effects.